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KMID : 0388220070140040384
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Journal of the Korean Rheumatism Association
2007 Volume.14 No. 4 p.384 ~ p.389
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A Case of Aplastic Anemia Associated with Systemic Lupus Erythematosus: Successful Treatement with Cyclosporine
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Lee Seung-Geun
Lee Jun-Hee
Back Seung-Hoon
Lee Joung-Wook
Cho Mi-La
Kim Seong-Il
Kim Ji-Ryang
Lee Bong-Eun
Seol Hee-Yun
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Abstract
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Systemic lupus erythematosus(SLE) is autoimmune disease in which involves systemic organs. Hematological manifestations are common in patients with SLE but aplastic anemia is very rare and, although various immunosuppressants have been tried, there is no established treatment in aplastic anemia associated with SLE. Furthermore, disease course and prognosis may be different from other aplastic anemia. A 42-year-old woman presented with fever, chilling, myalgia, general weakness, pancytopenia. Her bone marrow aspirate and biopsy revealed almost acellular bone marrow with rare foci of hematopoietic elements and she was diagnosed with SLE simultaneously. High-dose methyprednisolone, prednisolone and cyclophosphamide therapies had been unsuccessful in controlling pancytopenia. Cyclosproine was started and the aplastic anemia was responded. Now she was free of transfusion with more than 10 g/dL of hemoglobin.
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KEYWORD
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Systemic lupus erythematosus, Aplastic anemia, Cyclosporine
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